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Proceedings Paper

Detection of liver cancer tissue using silver nanoparticles-based surface-enhanced Raman spectroscopy
Author(s): Juqiang Lin; Fadian Liao; Qiuyong Ruan; Yongyi Zeng; Ling Li; Zufang Huang; Peng Lu; Rong Chen
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Paper Abstract

Early detection of hepatocellular carcinoma is difficult due to the absence of recognizable physical symptoms. In this study, Raman spectra of liver normal tissues and hepatocellular carcinoma tissues were measured by using silver nanoparticles based surface enhanced Raman spectroscopy (SERS), respectively. The mean Raman spectra of two groups are roughly similar. But the peaks intensity of hepatocellular carcinoma tissues at 722 cm-1 and 1049 cm-1 are obviously higher than those of normal tissues. Some peaks of hepatocellular carcinoma tissues have shifted by different degree. Besides, Raman peaks at 1004cm-1 had disappeared in normal tissue. The result suggested that SERS spectra can feature liver normal tissue and hepatocellular carcinoma tissue. Principal component analysis (PCA) coupled with linear discriminant analysis (LDA) was performed on the measured spectra. There were three most diagnostically significant PCs (PC3, PC9, and PC15, p<0.05) for discriminating these two groups. The diagnostic sensitivity and specificity both were 84.6%. The whole analysis of each sample needs less time-consumed and cost than other traditional methods in detecting and diagnosing HCC. The preliminary result suggests that SERS spectra can be a potential medical technology to detect and diagnose HCC.

Paper Details

Date Published: 18 November 2014
PDF: 6 pages
Proc. SPIE 9268, Optics in Health Care and Biomedical Optics VI, 92681D (18 November 2014); doi: 10.1117/12.2070844
Show Author Affiliations
Juqiang Lin, Fujian Normal Univ. (China)
Fadian Liao, Fujian Normal Univ. (China)
Qiuyong Ruan, Fujian Normal Univ. (China)
Yongyi Zeng, The First Affiliated Hospital of Fujian Medical Univ. (China)
Ling Li, The First Affiliated Hospital of Fujian Medical Univ. (China)
Zufang Huang, Fujian Normal Univ. (China)
Peng Lu, Fujian Normal Univ. (China)
Rong Chen, Fujian Normal Univ. (China)

Published in SPIE Proceedings Vol. 9268:
Optics in Health Care and Biomedical Optics VI
Qingming Luo; Xingde Li; Ying Gu; Yuguo Tang, Editor(s)

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