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Proceedings Paper

Using micro-Raman spectroscopy for nasopharyngeal cancerous tissue detection
Author(s): Shanshan Wu; Liqing Sun; Maowen Chen; Jia Lin; Gang Cao; Wei Huang; Rong Chen
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Paper Abstract

Micro-Raman spectroscopy is widely used for non-invasive tissue diagnosis and detection, as it provides detailed information about biomolecular composition, structure, and interaction of tissue. In this work, micro-Raman spectroscopy was used to investigate non-cancerous and cancerous nasopharyngeal tissues. The obtained nasopharyngeal tissue samples in vitro are divided into two groups: cancerous (n=12, undifferentiated non-keratinizing carcinomas) and non-cancerous (n=10, 7 chronic inflammations, 2 lymphomas and 1 lymphocytosis). Firstly, we analyzed the Raman spectra in the fingerprint (FP, 400-1800cm-1) region acquired. Preliminary results showed that there are some spectral differences in different pathological conditions. Furthermore, Raman spectra from cancerous and non-cancerous nasopharyngeal tissue in the high wavenumber region (HW, 2800-3100cm-1) were also reported for the first time. After detailed analysis, we achieved significant differences in Raman bands at 2854, 2874, 2934, and 3067cm-1 between cancerous and non-cancerous nasopharyngeal tissues. This study demonstrates that both fingerprint and high wavenumber regions of micro-Raman spectroscopy have the potential for the early detection of nasopharyngeal carcinomas.

Paper Details

Date Published: 17 September 2014
PDF: 6 pages
Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 923028 (17 September 2014); doi: 10.1117/12.2069229
Show Author Affiliations
Shanshan Wu, Fujian Normal Univ. (China)
Liqing Sun, Fuzhou First Hospital (China)
Maowen Chen, Fujian Normal Univ. (China)
Jia Lin, Fujian Normal Univ. (China)
Gang Cao, Fujian Normal Univ. (China)
Wei Huang, Fujian Normal Univ. (China)
Fujian Metrology Institute (China)
Rong Chen, Fujian Normal Univ. (China)

Published in SPIE Proceedings Vol. 9230:
Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014)
Qingming Luo; Lihong V. Wang; Valery V. Tuchin, Editor(s)

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