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Proceedings Paper

Intravascular photoacoustic tomography for characterization of atherosclerotic lipid and inflammation
Author(s): Jian Zhang; Huan Qin; Yujiao Shi; Sihua Yang; Da Xing
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Paper Abstract

Photoacoustic imaging is a fast growing imaging technology depending on its high optical resolution of optics while taking the advantage of the high penetration depth of ultrasound. In this paper, we demonstrate the new progress in the photoacoustic imaging. Atherosclerosis is characterized by a progressive build-up of lipid in the arterial wall, which is known as plaque. Histological studies demonstrate that the primary cause of acute cardiovascular events is the rupture of atherosclerotic plaques. Lipid and inflammation within the plaque are related to influence the propensity of plaques to disrupt. Photoacoustic intravascular tomography (IVPAT) holds a great advantage in providing comprehensive morphological and functional information of plaques. Lipid relative concentration maps of atherosclerotic aorta were obtained and compared with histology. Furthermore, by selectively targeting the intravascular inflammatory cytokines, IVPAT is also capable of mapping the inflamed area and determining the degree of inflammation.

Paper Details

Date Published: 17 September 2014
PDF: 9 pages
Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 923027 (17 September 2014); doi: 10.1117/12.2069044
Show Author Affiliations
Jian Zhang, South China Normal Univ. (China)
Huan Qin, South China Normal Univ. (China)
Yujiao Shi, South China Normal Univ. (China)
Sihua Yang, South China Normal Univ. (China)
Da Xing, South China Normal Univ. (China)

Published in SPIE Proceedings Vol. 9230:
Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014)
Qingming Luo; Lihong V. Wang; Valery V. Tuchin, Editor(s)

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