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Proceedings Paper

Reducing the orientation influence of Mueller matrix measurements for anisotropic scattering media
Author(s): Minghao Sun; Honghui He; Nan Zeng; E. Du; Yonghong He; Hui Ma
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Paper Abstract

Mueller matrix polarimetry techniques contain rich micro-structural information of samples, such as the sizes and refractive indices of scatterers. Recently, Mueller matrix imaging methods have shown great potentials as powerful tools for biomedical diagnosis. However, the orientations of anisotropic fibrous structures in tissues have prominent influence on Mueller matrix measurements, resulting in difficulties for extracting micro-structural information effectively. In this paper, we apply the backscattering Mueller matrix imaging technique to biological samples with different microstructures, such as chicken heart muscle, bovine skeletal muscle, porcine liver and fat tissues. Experimental results show that the directions of the muscle fibers have prominent influence on the Mueller matrix elements. In order to reduce the orientation influence, we adopt the rotation-independent MMT and RLPI parameters, which were proposed in our previous studies, to the tissue samples. Preliminary results in this paper show that the orientation-independent parameters and their statistic features are helpful for analyzing the tissues to obtain their micro-structural properties. Since the micro-structure variations are often related to the pathological changes, the method can be applied to microscope imaging techniques and used to detect abnormal tissues such as cancer and other lesions for diagnosis purposes.

Paper Details

Date Published: 17 September 2014
PDF: 9 pages
Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 92300O (17 September 2014); doi: 10.1117/12.2068989
Show Author Affiliations
Minghao Sun, Tsinghua Univ. (China)
Honghui He, Tsinghua Univ. (China)
Nan Zeng, Tsinghua Univ. (China)
E. Du, Tsinghua Univ. (China)
Yonghong He, Tsinghua Univ. (China)
Hui Ma, Tsinghua Univ. (China)

Published in SPIE Proceedings Vol. 9230:
Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014)
Qingming Luo; Lihong V. Wang; Valery V. Tuchin, Editor(s)

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