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Proceedings Paper

Adrenergic mechanism responsible for pathological alteration in gastric mucosal blood flow in rats with ulcer bleeding
Author(s): O. V. Semyachkina-Glushkovskaya; A. N. Pavlov; I. A. Semyachkin-Glushkovskiy; A. S. Gekalyuk; M. V. Ulanova; V. V. Lychagov; V. V. Tuchin
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Paper Abstract

The adrenergic system plays an important role in regulation of central and peripheral circulation in normal state and during hemorrhage. Because the impaired gastric mucosal blood flow (GMBF) is the major cause of gastroduodenal lesions, including ulcer bleeding (UB), we studied the adrenergic mechanism responsible for regulation of GMBF in rats with a model of stress-induced UB (SUB) using the laser Doppler flowmetry (LDF). First, we examined the effect of adrenaline on GMBF in rats under normal state and during UB. In all healthy animals the submucosal adrenaline injection caused a decrease in local GMBF. During UB the submucosal injection of adrenaline was accompanied by less pronounced GMBF suppression in 30,3% rats with SUB vs. healthy ones. In 69,7% rats with SUB we observed the increase in local GMBF after submucosal injection of adrenaline. Second, we studied the sensitivity of gastric β2-adrenoreceptors and the activity of two factors which are involved in β2-adrenomediated vasorelaxation-KATP -channels and NO. The effects of submucosal injection of isoproterenol, ICI118551 and glybenclamide on GMBF as well as NO levels in gastric tissue were significantly elevated in rats with SUB vs. healthy rats. Thus, our results indicate that high activation of gastric β2-adrenoreceptors associated with the increased vascular KATP -channels activity and elevated NO production is the important adrenergic mechanism implicated in the pathogenesis of UB.

Paper Details

Date Published: 17 September 2014
PDF: 8 pages
Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 92300H (17 September 2014); doi: 10.1117/12.2068824
Show Author Affiliations
O. V. Semyachkina-Glushkovskaya, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
A. N. Pavlov, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
Saratov State Technical Univ. (Russian Federation)
I. A. Semyachkin-Glushkovskiy, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
A. S. Gekalyuk, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
M. V. Ulanova, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
V. V. Lychagov, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
V. V. Tuchin, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
Univ. of Oulu (Finland)


Published in SPIE Proceedings Vol. 9230:
Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014)
Qingming Luo; Lihong V. Wang; Valery V. Tuchin, Editor(s)

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