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Proceedings Paper

Preparation of multifunctional upconversion nanoconstruct for in vitro and in vivo imaging and photodynamic therapy induced by near-infrared light
Author(s): Deyan Yin; Shanshan Huang; Ying Zhang; Yueqing Gu
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Paper Abstract

Upconversion nanoparticles (UCNPs) have attracted much attention as novel contrast agents for low-background biomedical imaging and potential photosensitizer carriers for photodynamic therapy (PDT) in deep tissues. In this work, firstly we synthesized NaYF4:Yb3+,Tm3+@NaYF4:Yb3+,Er3+ core-shell structured UCNPs with multiple emission peaks (e.g. 480, 539, 654 and 800 nm) by a seeded growth approach. By coating folate-modified amphiphilic chitosan (FASOC) on UCNPs, the as-prepared UCNPs were favorably endowed with good water solubility and the enhanced tumor-selectivity to cancer cells that overexpressed folate receptor. Then, water-insoluble photosensitizer zinc(II) phthalocyanine (ZnPc) was loaded into the FASOC-UCNPs via hydrophobic interactions for potential near-infrared light induced photodynamic therapy (PDT). Our results indicate that the multifunctional FASOC-UCNP-ZnPc nanoconstruct has efficient NIR-to-NIR upconversion luminescence and PDT abilities, which could be potentially employed as a theranostic platform for cancer treatment.

Paper Details

Date Published: 17 September 2014
PDF: 13 pages
Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 923018 (17 September 2014); doi: 10.1117/12.2068692
Show Author Affiliations
Deyan Yin, China Pharmaceutical Univ. (China)
Shanshan Huang, China Pharmaceutical Univ. (China)
Ying Zhang, China Pharmaceutical Univ. (China)
Yueqing Gu, China Pharmaceutical Univ. (China)

Published in SPIE Proceedings Vol. 9230:
Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014)
Qingming Luo; Lihong V. Wang; Valery V. Tuchin, Editor(s)

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