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Proceedings Paper

Label-free visualization of collagen in submucosa as a potential diagnostic marker for early detection of colorectal cancer
Author(s): Jingting Qiu; Yinghong Yang; Weizhong Jiang; Changyin Feng; Zhifen Chen; Guoxian Guan; Xiaoqin Zhu; Shuangmu Zhuo; Jianxin Chen
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Paper Abstract

The collagen signature in colorectal submucosa is changed due to remodeling of the extracellular matrix during the malignant process and plays an important role in noninvasive early detection of human colorectal cancer. In this work, multiphoton microscopy (MPM) was used to monitor the changes of collagen in normal colorectal submucosa (NCS) and cancerous colorectal submucosa (CCS). What’s more, the collagen content was quantitatively measured. It was found that in CCS the morphology of collagen becomes much looser and the collagen content is significantly reduced compared to NCS. These results suggest that MPM has the ability to provide collagen signature as a potential diagnostic marker for early detection of colorectal cancer.

Paper Details

Date Published: 17 September 2014
PDF: 5 pages
Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 92301M (17 September 2014); doi: 10.1117/12.2068498
Show Author Affiliations
Jingting Qiu, Fujian Normal Univ. (China)
Yinghong Yang, The Affiliated Union Hospital of Fujian Medical Univ. (China)
Weizhong Jiang, The Affiliated Union Hospital of Fujian Medical Univ. (China)
Changyin Feng, The Affiliated Union Hospital of Fujian Medical Univ. (China)
Zhifen Chen, The Affiliated Union Hospital of Fujian Medical Univ. (China)
Guoxian Guan, The Affiliated Union Hospital of Fujian Medical Univ. (China)
Xiaoqin Zhu, Fujian Normal Univ. (China)
Shuangmu Zhuo, Fujian Normal Univ. (China)
Jianxin Chen, Fujian Normal Univ. (China)


Published in SPIE Proceedings Vol. 9230:
Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014)
Qingming Luo; Lihong V. Wang; Valery V. Tuchin, Editor(s)

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