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Proceedings Paper

Imaging of surgical margin in pancreatic metastasis using two-photon excited fluorescence microscopy
Author(s): Jing Chen; Zhipeng Hong; Hong Chen; Youting Chen; Yahao Xu; Xiaoqin Zhu; Shuangmu Zhuo; Zheng Shi; Jianxin Chen
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Paper Abstract

Two-photon excited fluorescence (TPEF) microscopy, has become a powerful tool for imaging unstained tissue samples at subcellular level in biomedical research. The purpose of this study was to determine whether TPEF imaging of histological sections without H-E staining can be used to identify the boundary between normal pancreas and pancreatic metastasis from renal cell carcinoma (RCC). The typical features such as the significant increase of cancerous nests, the absence of pancreatic ductal, the appearance of cancer cells were observed to present the boundary between normal pancreas and pancreatic metastasis from RCC. These results correlated well with the corresponding histological outcomes. With the advent of clinically miniaturized TPEF microscopy and integrative endoscopy, TPEF microscopy has the potential application on surgical location of pancreatic metastasis from RCC in the near future.

Paper Details

Date Published: 17 September 2014
PDF: 5 pages
Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 92301L (17 September 2014); doi: 10.1117/12.2068497
Show Author Affiliations
Jing Chen, Fujian Normal Univ. (China)
Zhipeng Hong, The First Affiliated Hospital of Fujian Medical Univ. (China)
Hong Chen, The First Affiliated Hospital of Fujian Medical Univ. (China)
Youting Chen, The First Affiliated Hospital of Fujian Medical Univ. (China)
Yahao Xu, Fujian Normal Univ. (China)
Xiaoqin Zhu, Fujian Normal Univ. (China)
Shuangmu Zhuo, The First Affiliated Hospital of Fujian Medical Univ. (China)
Zheng Shi, The First Affiliated Hospital of Fujian Medical Univ. (China)
Jianxin Chen, Fujian Normal Univ. (China)


Published in SPIE Proceedings Vol. 9230:
Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014)
Qingming Luo; Lihong V. Wang; Valery V. Tuchin, Editor(s)

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