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Proceedings Paper

Pharmacokinetic studies of delta-aminolevulinic-acid-induced protoporphyrin IX build-up in some malignant tumors
Author(s): Katarina Svanberg; Laudelina Pais Clemente; Manuel P. Clemente; Ingrid Wang-Nordman; Trond Warloe; Stefan Andersson-Engels; Roger Berg; Johan Moan; Qian Peng; Sune Svanberg
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Paper Abstract

Laser-induced fluorescence was used for the monitoring of the (delta) - amino levulinic acid (ALA)-induce protoporphyrin IX (PpIX) build-up in nonmelanoma malignant tumors of the skin and some cancers in the head and neck region. An optical-fiber based point monitoring system was utilized in the recording of fluorescence spectral at different time intervals after the administration of ALA. In the cases of skin tumors ALA was normally applied topically to the area. Only in one patient with an aggressive skin tumor ALA was administered intravenously. For the PpIX induction in the head and neck tumors the ALA was given orally. An example of a tumor fluorescence image is also presented.

Paper Details

Date Published: 12 April 1995
PDF: 13 pages
Proc. SPIE 2387, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II, (12 April 1995); doi: 10.1117/12.206834
Show Author Affiliations
Katarina Svanberg, Lund Univ. Hospital (Sweden)
Laudelina Pais Clemente, Oporto School of Medicine (Portugal)
Manuel P. Clemente, Oporto School of Medicine (Portugal)
Ingrid Wang-Nordman, Lund Univ. Hospital (Sweden)
Trond Warloe, Norwegian Radium Hospital (Norway)
Stefan Andersson-Engels, Lund Institute of Technology (Sweden)
Roger Berg, Lund Institute of Technology (Sweden)
Johan Moan, Norwegian Radium Hospital (Norway)
Qian Peng, Norwegian Radium Hospital (Norway)
Sune Svanberg, Lund Institute of Technology (Sweden)

Published in SPIE Proceedings Vol. 2387:
Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II
Robert R. Alfano, Editor(s)

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