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Proceedings Paper

Near-infrared monitoring of hemoglobin content in the kidney during ischemia
Author(s): Wendy J. Snyder; Jean-Michel I. Maarek; Sandor G. Vari; Laura Marcu; Thanassis Papaioannou; Vani R. Pergadia; Warren S. Grundfest
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Paper Abstract

Near infrared spectroscopy was used to monitor changes in hemoglobin concentration in the kidney of 9 anesthetized rabbits during ischemic conditions. Laser diodes (775, 810, 862, and 904 nm) were placed on the surface of the kidney, the transmitted light was detected by a photomultiplier. Three stages of ischemia were induced in the kidney by occluding the abdominal aorta to approximately 1/3, 2/3 and total occlusion. Hemoglobin content was monitored during 10 minutes of occlusion followed by 10 minutes of recovery. The occlusions resulted in an average decrease in blood pressure of 36%, 53% and 100% in the abdominal aorta. The partial occlusions resulted in an increasing trend in total hemoglobin content during the 10 minutes occlusion followed by a return to baseline hemoglobin concentration. Within the first 30 seconds of the total occlusion maneuver, an immediate decrease in hemoglobin content was observed. During the occlusion the hemoglobin content increases slowly, corresponding to an increase in reduced hemoglobin content. Oxygenated hemoglobin content remained constant during the occlusion and increased immediately when the occlusion was released.

Paper Details

Date Published: 12 April 1995
PDF: 7 pages
Proc. SPIE 2387, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II, (12 April 1995); doi: 10.1117/12.206827
Show Author Affiliations
Wendy J. Snyder, Univ. of Southern California (United States)
Cedars-Sinai Medical Ctr. (United States)
Jean-Michel I. Maarek, Univ. of Southern California (United States)
Cedars-Sinai Medical Ctr. (United States)
Sandor G. Vari, Univ. of Southern California (United States)
Cedars-Sinai Medical Ctr. (United States)
Laura Marcu, Univ. of Southern California (United States)
Cedars-Sinai Medical Ctr. (United States)
Thanassis Papaioannou, Univ. of Southern California (United States)
Cedars-Sinai Medical Ctr. (United States)
Vani R. Pergadia, Univ. of Southern California (United States)
Cedars-Sinai Medical Ctr. (United States)
Warren S. Grundfest, Univ. of Southern California (United States)
Cedars-Sinai Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 2387:
Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II
Robert R. Alfano, Editor(s)

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