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Proceedings Paper

Can we get more tissue biochemistry information from in-vivo near-infrared spectra?
Author(s): Jeffrey W. Hall; Valentina Quaresima; Marco Ferrari
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Paper Abstract

We have compared in vivo spectra of the human forearm, brain, breast and blood-perfluorocarbon exchanged cat brain with reference spectra of deoxyhemoglobin, oxyhemoglobin, triglycerides, water and albumin to identify spectral features related to tissue biochemistry. From these investigations it is evident that bands due to fat, protein and water overlap the deoxyhemoglobin band at 760 nm. While these overlapping absorptions may be insignificant in whole blood, there is a potential for spectral interference in in vivo studies. Furthermore, unique features related the protein, lipids and water can be used to image breast tissue composition. The ability to resolve the overlapping absorption bands appears easily accomplished by using derivative mathematical approaches.

Paper Details

Date Published: 12 April 1995
PDF: 7 pages
Proc. SPIE 2387, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II, (12 April 1995); doi: 10.1117/12.206826
Show Author Affiliations
Jeffrey W. Hall, Mount Sinai Hospital (Canada)
NIRSystems, Inc. (United States)
Valentina Quaresima, Univ. L'Aquila (Italy)
Marco Ferrari, Univ. L'Aquila (Italy)


Published in SPIE Proceedings Vol. 2387:
Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II
Robert R. Alfano, Editor(s)

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