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Proceedings Paper

In-vivo cancer diagnosis of the esophagus using laser-induced fluorescence
Author(s): Tuan Vo-Dinh; Masoud Panjehpour; Bergein F. Overholt; Paul F. Buckley; Donna H. Edwards
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Paper Abstract

Laser-induced fluorescence (LIF) was used for direct in-vivo cancer diagnosis of the esophagus without requiring biopsy. The methodology was applied to differentiate normal and malignant tumors of the esophagus. Endogenous fluorescence of normal and malignant tissues were measured directly using a fiberoptic probe inserted through an endoscope. The measurements were performed in vivo during routine endoscopy. Detection of the fluorescence signal from the tissue was performed using laser excitation. The results of this LIF approach were compared with histopathology results of the biopsy samples and indicated excellent agreement in the classification of normal and malignant tumors for the samples investigated. The LIF procedure could lead to the development of a rapid and cost-effective technique for cancer diagnosis.

Paper Details

Date Published: 12 April 1995
PDF: 7 pages
Proc. SPIE 2387, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II, (12 April 1995); doi: 10.1117/12.206821
Show Author Affiliations
Tuan Vo-Dinh, Oak Ridge National Lab. (United States)
Masoud Panjehpour, Thompson Cancer Survival Ctr. (United States)
Bergein F. Overholt, Thompson Cancer Survival Ctr. (United States)
Paul F. Buckley, Thompson Cancer Survival Ctr. (United States)
Donna H. Edwards, Thompson Cancer Survival Ctr. (United States)


Published in SPIE Proceedings Vol. 2387:
Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II
Robert R. Alfano, Editor(s)

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