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Proceedings Paper

Photodynamic antimicrobial chemotherapy using zinc phthalocyanine derivative for bacterial skin infection
Author(s): Zhuo Chen; Yaxin Zhang; Linsen Li; Shanyong Zhou; Jincan Chen; Ping Hu; Mingdong Huang
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Paper Abstract

Folliculitis, furunculosis and acne vulgaris are very common skin disorders of the hair follicles and are associated with large grease-producing (sebaceous) glands. Although the detailed mechanisms involved these skin disorders are not fully understood, it is believed that the bacteria Propionibacterium acnes and Staphylococcus aureus are the key pathogenic factors involved. Conventional treatments targeting the pathogenic factors include a variety of topical and oral medications such as antibiotics. The wide use of antibiotics leads to bacterial resistance, and hence there is a need for new alternatives in above bacterial skin treatment. Photodynamic antimicrobial chemotherapy (PACT) is based on an initial photosensitization of the infected area, followed by irradiation with visible light, producing singlet oxygen which is cytotoxic to bacteria. Herein we reported a zinc phthalocyanine derivative, pentalysine β-carbonylphthalocyanine zinc (ZnPc-(Lys)5) and its PACT effect for the bacteria involved in these skin infections. Our results demonstrated strong bactericidal effects of this photosensitizer on both strains of the bacteria, suggesting ZnPc-(Lys)5 as a promising antimicrobial photosensitizer for the treatment of infectious diseases caused by these bacteria.

Paper Details

Date Published: 17 September 2014
PDF: 7 pages
Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 923017 (17 September 2014); doi: 10.1117/12.2068160
Show Author Affiliations
Zhuo Chen, Fujian Institute of Research on the Structure of Matter (China)
Yaxin Zhang, Fujian Institute of Research on the Structure of Matter (China)
Linsen Li, Shenyang Medical College (China)
Shanyong Zhou, Fujian Institute of Research on the Structure of Matter (China)
Jincan Chen, Fujian Institute of Research on the Structure of Matter (China)
Ping Hu, Fujian Institute of Research on the Structure of Matter (China)
Mingdong Huang, Fujian Institute of Research on the Structure of Matter (China)


Published in SPIE Proceedings Vol. 9230:
Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014)
Qingming Luo; Lihong V. Wang; Valery V. Tuchin, Editor(s)

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