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Proceedings Paper

Fabrication of a multiplexed microfluidic system for scaled up production of cross-linked biocatalytic microspheres
Author(s): Mesuli B. Mbanjwa; Hao Chen; Louis Fourie; Sibusiso Ngwenya; Kevin Land
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Paper Abstract

Multiplexed or parallelised droplet microfluidic systems allow for increased throughput in the production of emulsions and microparticles, while maintaining a small footprint and utilising minimal ancillary equipment. The current paper demonstrates the design and fabrication of a multiplexed microfluidic system for producing biocatalytic microspheres. The microfluidic system consists of an array of 10 parallel microfluidic circuits, for simultaneous operation to demonstrate increased production throughput. The flow distribution was achieved using a principle of reservoirs supplying individual microfluidic circuits. The microfluidic devices were fabricated in poly (dimethylsiloxane) (PDMS) using soft lithography techniques. The consistency of the flow distribution was determined by measuring the size variations of the microspheres produced. The coefficient of variation of the particles was determined to be 9%, an indication of consistent particle formation and good flow distribution between the 10 microfluidic circuits.

Paper Details

Date Published: 23 June 2014
PDF: 7 pages
Proc. SPIE 9257, Sensors, MEMS and Electro-Optical Systems, 92570M (23 June 2014); doi: 10.1117/12.2065809
Show Author Affiliations
Mesuli B. Mbanjwa, Council for Scientific and Industrial Research (South Africa)
Univ. of the Witwatersrand (South Africa)
Hao Chen, Council for Scientific and Industrial Research (South Africa)
Louis Fourie, Council for Scientific and Industrial Research (South Africa)
Sibusiso Ngwenya, Council for Scientific and Industrial Research (South Africa)
Kevin Land, Council for Scientific and Industrial Research (South Africa)


Published in SPIE Proceedings Vol. 9257:
Sensors, MEMS and Electro-Optical Systems
Monuko du Plessis, Editor(s)

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