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Proceedings Paper

Investigation of thermal denaturation of solid oxytocin by terahertz dielectric spectroscopy
Author(s): Xiangjun Li; Xiaojie Yang; Jianjun Liu; Yong Du; Zhi Hong
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Paper Abstract

We investigate the thermal denaturation of solid oxytocin using terahertz time domain spectroscopy(THz-TDS). When the peptide is heated up from 25°C to 107°C and cooled down to 25°C again, an irreversible decrease in its THz absorption coefficient and refractive index is observed. The corresponding frequency-dependent permittivity during heating is fitted by the Debye model with single relaxation time. The relaxation times during temperature rising agree very well with Arrhenius equation with the activation energy of 3.12kJ/(K•mol) as an indicator for its thermal denaturation difficulty.

Paper Details

Date Published: 21 August 2014
PDF: 7 pages
Proc. SPIE 9233, International Symposium on Photonics and Optoelectronics 2014, 92330S (21 August 2014); doi: 10.1117/12.2065231
Show Author Affiliations
Xiangjun Li, China Jiliang Univ. (China)
Xiaojie Yang, China Jiliang Univ. (China)
Jianjun Liu, China Jiliang Univ. (China)
Yong Du, China Jiliang Univ. (China)
Zhi Hong, China Jiliang Univ. (China)


Published in SPIE Proceedings Vol. 9233:
International Symposium on Photonics and Optoelectronics 2014
Zhiping Zhou, Editor(s)

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