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Proceedings Paper

Controlling the intracellular fate of nano-bioconjugates: pathways for realizing nanoparticle-mediated theranostics
Author(s): James B. Delehanty; Juan B. Blanco-Canosa; Christopher E. Bradburne; Kimihiro Susumu; Michael H. Stewart; Duane E. Prasuhn; Philip E. Dawson; Igor L. Medintz
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Paper Abstract

For nanomaterials to realize their full potential in disease diagnosis and drug delivery applications, one must be able to exert fine control over their cellular delivery, localization and long-term fate in biological systems. Our laboratory has been active in developing methodologies for the controlled and site-specific delivery of a range of nanomaterials (e.g., quantum dots, colloidal gold, nematic liquid crystals) for cellular labeling, imaging and sensing. This talk will highlight several examples from these efforts and will demonstrate the use of peptide- and protein-mediated facilitated delivery of nanomaterials to discrete cellular locations including the endocytic pathway, the plasma membrane and the cellular cytosol. The implications of the ability to exert fine control over nanomaterial constructs in biological settings will be discussed with a particular focus on their use in nanoparticle-based theranostics.

Paper Details

Date Published: 27 August 2014
PDF: 6 pages
Proc. SPIE 9166, Biosensing and Nanomedicine VII, 91660A (27 August 2014); doi: 10.1117/12.2064372
Show Author Affiliations
James B. Delehanty, U.S. Naval Research Lab. (United States)
Juan B. Blanco-Canosa, The Scripps Research Institute (United States)
Christopher E. Bradburne, U.S. Naval Research Lab. (United States)
Kimihiro Susumu, U.S. Naval Research Lab. (United States)
Sotera Defense Solutions
Michael H. Stewart, U.S. Naval Research Lab. (United States)
Duane E. Prasuhn, U.S. Naval Research Lab. (United States)
Philip E. Dawson, The Scripps Research Institute (United States)
Igor L. Medintz, U.S. Naval Research Lab. (United States)


Published in SPIE Proceedings Vol. 9166:
Biosensing and Nanomedicine VII
Hooman Mohseni; Massoud H. Agahi; Manijeh Razeghi, Editor(s)

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