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Proceedings Paper

The whispering gallery mode biosensor: label-free detection from virus to single protein
Author(s): S. Holler; V. R. Dantham; D. Keng; V. Kolchenko; S. Arnold; Brigid Mulroe; M. Paspaley-Grbavac
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Paper Abstract

The whispering gallery mode (WGM) biosensor is a micro-optical platform capable of sensitive label-free detection of biological particles. Described by the reactive sensing principle (RSP), this analytic formulation quantifies the response of the system to the adsorption of bioparticles. Guided by the RSP, the WGM biosensor enabling from detection of virus (e.g., Human Papillomavirus, HPV) to the ultimate goal of single protein detection. The latter was derived from insights into the RSP, which resulted in the development of a hybrid plasmonic WGM biosensor, which has recently demonstrated detection of individual protein cancer markers. Enhancements from bound gold nanoparticles provide the sensitivity to detect single protein molecules (66 kDa) with good signal-to-noise (S/N > 10), and project that detection of proteins as small as 5 kDa.

Paper Details

Date Published: 28 August 2014
PDF: 8 pages
Proc. SPIE 9166, Biosensing and Nanomedicine VII, 91660O (28 August 2014); doi: 10.1117/12.2061477
Show Author Affiliations
S. Holler, Fordham Univ. (United States)
V. R. Dantham, Polytechnic Institute of New York Univ. (United States)
D. Keng, Polytechnic Institute of New York Univ. (United States)
V. Kolchenko, New York City College of Technology (United States)
S. Arnold, Polytechnic Institute of New York Univ. (United States)
Brigid Mulroe, Fordham Univ. (United States)
M. Paspaley-Grbavac, Fordham Univ. (United States)


Published in SPIE Proceedings Vol. 9166:
Biosensing and Nanomedicine VII
Hooman Mohseni; Massoud H. Agahi; Manijeh Razeghi, Editor(s)

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