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Proceedings Paper

Reflection-type long period grating biosensor for the detection of drug resistant bacteria: The Opto-bacteria Project
Author(s): M. Consales; G. Quero; S. Zuppolini; L. Sansone; A. Borriello; M. Giordano; A. Venturelli; A. Cusano
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Paper Abstract

We report on the development of a multilayer coated reflection-type long period fiber grating (LPG) biosensor, useful for the detection of antibiotic resistance bacteria. A standard LPG is first transformed in a more practical probe working in reflection mode, then it is coated by a primary layer of aPS and a secondary layer of PMMA in order to increase its surrounding refractive index sensitivity and at the same time provide the necessary conditions for a correct biofunctionalization. Standard linkage chemistry has been applied to anchor the bioreceptors on the probe surface. We show some preliminary results demonstrating the capability of our LPG biosensor to successfully monitor all the biological steps of the biomolecular experiments, including β-lactamase binding detection tests.

Paper Details

Date Published: 2 June 2014
PDF: 4 pages
Proc. SPIE 9157, 23rd International Conference on Optical Fibre Sensors, 91575G (2 June 2014); doi: 10.1117/12.2059783
Show Author Affiliations
M. Consales, Univ. degli Studi del Sannio (Italy)
G. Quero, Univ. degli Studi del Sannio (Italy)
S. Zuppolini, Istituto per i Materiali Compositi e Biomedici. CNR (Italy)
L. Sansone, Istituto per i Materiali Compositi e Biomedici. CNR (Italy)
A. Borriello, Istituto per i Materiali Compositi e Biomedici. CNR (Italy)
M. Giordano, Optosmart S.r.l. (Italy)
A. Venturelli, Tydock Pharma S.r.l (Italy)
A. Cusano, Univ. degli Studi del Sannio (Italy)


Published in SPIE Proceedings Vol. 9157:
23rd International Conference on Optical Fibre Sensors
José M. López-Higuera; Julian D. C. Jones; Manuel López-Amo; José Luis Santos, Editor(s)

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