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Proceedings Paper

Bacteriophage adhesin-coated long-period gratings for bacterial lipopolysaccharide recognition
Author(s): Marcin Koba; Mateusz Śmietana; Ewa Brzozowska; Sabina Górska; Predrag Mikulic; Wojtek J. Bock
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Paper Abstract

In this work we report an application of the optical fiber long-period gratings (LPGs) working near the dispersion turning point of higher order cladding modes for bacterial lipopolysaccharide (LPS) recognition. We show that when the LPG is functionalized with the bacteriophage adhesin, it is capable of very specific LPS detection. Thus, we compare label-free binding effect for specific to the adhesin LPS-positive and non-specific LPS-negative. The resonance wavelength shift induced by the LPS-positive reaches 2.9 nm, while for LPS-negative the shift is negligible. The LPG-based sensing structure allows for monitoring of the binding phenomenon in real time and with good accuracy.

Paper Details

Date Published: 2 June 2014
PDF: 4 pages
Proc. SPIE 9157, 23rd International Conference on Optical Fibre Sensors, 915757 (2 June 2014); doi: 10.1117/12.2059618
Show Author Affiliations
Marcin Koba, Univ. du Québec en Outaouais (Canada)
Mateusz Śmietana, Warsaw Univ. of Technology (Poland)
Ewa Brzozowska, Institute of Immunology and Experimental Therapy (Poland)
Sabina Górska, Institute of Immunology and Experimental Therapy (Poland)
Predrag Mikulic, Univ. du Québec en Outaouais (Canada)
Wojtek J. Bock, Univ. du Québec en Outaouais (Canada)


Published in SPIE Proceedings Vol. 9157:
23rd International Conference on Optical Fibre Sensors
José M. López-Higuera; Julian D. C. Jones; Manuel López-Amo; José Luis Santos, Editor(s)

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