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Proceedings Paper

UV resonance Raman sensing of pharmaceutical drugs in hollow fibers
Author(s): D. Yan; J. Popp; T. Frosch
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Paper Abstract

We report about the experimental combination of UV resonance Raman sensing (UV-RRS) and fiber enhanced Raman sensing (FERS) on pharmaceuticals. The results show that the chemical sensitivity is highly improved and at the same time the sample volume is reduced compared to conventional measurements. A hundreds-fold improvement of the limit of detection (LOD) has been achieved with the combination of resonance Raman enhancement and fiber enhancement. The enhanced Raman signal has a reliable linear relationship with the concentration of the analyte, and therefore shows great potential for quantitative analysis of pharmaceuticals.

Paper Details

Date Published: 2 June 2014
PDF: 4 pages
Proc. SPIE 9157, 23rd International Conference on Optical Fibre Sensors, 915755 (2 June 2014); doi: 10.1117/12.2059574
Show Author Affiliations
D. Yan, Institut für Photonische Technologien e.V. (Germany)
J. Popp, Institut für Photonische Technologien e.V. (Germany)
Friedrich-Schiller Univ. (Germany)
T. Frosch, Institut für Photonische Technologien e.V. (Germany)
Friedrich-Schiller Univ. (Germany)


Published in SPIE Proceedings Vol. 9157:
23rd International Conference on Optical Fibre Sensors
José M. López-Higuera; Julian D. C. Jones; Manuel López-Amo; José Luis Santos, Editor(s)

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