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Proceedings Paper

Real-time monitoring of intracellular signal transduction in PC12 cells by non-adiabatic tapered optical fiber biosensor
Author(s): M. I. Zibaii; H. Latifi; A. Asadollahi; Z. Noraeipoor; L. Dargahi
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Paper Abstract

Real-time observation of intracellular process of signal transduction is very useful for biomedical and pharmaceutical applications as well as for basic research work of cell biology. For feasible and reagentless observation of intracellular alterations in real time, we examined the use of a nonadiabatic tapered optical fiber (NATOF) biosensor for monitoring of intracellular signal transduction that was mainly translocation of protein kinase C via refractive index change in PC12 cells adhered on tapered fiber sensor without any indicator reagent. PC12 cells were stimulated with KCl . Our results suggest that complex intracellular reactions could be real-time monitored and characterized by NATOF biosensor.

Paper Details

Date Published: 2 June 2014
PDF: 4 pages
Proc. SPIE 9157, 23rd International Conference on Optical Fibre Sensors, 91574I (2 June 2014); doi: 10.1117/12.2058939
Show Author Affiliations
M. I. Zibaii, Shahid Beheshti Univ. (Iran, Islamic Republic of)
H. Latifi, Shahid Beheshti Univ. (Iran, Islamic Republic of)
A. Asadollahi, Shahid Beheshti Univ. (Iran, Islamic Republic of)
Z. Noraeipoor, Shahid Beheshti Univ. (Iran, Islamic Republic of)
L. Dargahi, Shahid Beheshti Univ. of Medical Sciences (Iran, Islamic Republic of)


Published in SPIE Proceedings Vol. 9157:
23rd International Conference on Optical Fibre Sensors
José M. López-Higuera; Julian D. C. Jones; Manuel López-Amo; José Luis Santos, Editor(s)

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