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Proceedings Paper

Performance evaluation of fluorescence tomography in a Siemens Inveon multimodality scanner
Author(s): Yujie Lu; Chinmay Darne; I-Chih Tan; Banghe Zhu; John Rasmussen; Eva M. Sevick-Muraca
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Paper Abstract

A tri-modal (PET/CT/Optical) small animal tomographic imaging system was developed by integrating our advanced non-contact intensified CCD (ICCD) frequency-domain fluorescence imaging components into a Siemens Inveon scanner. We performed a performance evaluation of the developed imaging system by using the developed regularization-free high-order radiative-transfer-based reconstruction algorithm and custom solid phantoms. Our results show that frequency-domain photon migration (FDPM) fluorescence tomography can achieve better tomographic images with less artifacts and more precise fluorescent source localization compared to the continuous-wave counterpart. The developed multimodal tomographic imaging system provides a powerful tool for translational biomedical research.

Paper Details

Date Published: 19 May 2014
PDF: 4 pages
Proc. SPIE 9155, Translational Biophotonics, 91551H (19 May 2014); doi: 10.1117/12.2057818
Show Author Affiliations
Yujie Lu, The Univ. of Texas Health Science Ctr. at Houston (United States)
Chinmay Darne, The Univ. of Texas Health Science Ctr. at Houston (United States)
I-Chih Tan, The Univ. of Texas Health Science Ctr. at Houston (United States)
Banghe Zhu, The Univ. of Texas Health Science Ctr. at Houston (United States)
John Rasmussen, The Univ. of Texas Health Science Ctr. at Houston (United States)
Eva M. Sevick-Muraca, The Univ. of Texas Health Science Ctr. at Houston (United States)


Published in SPIE Proceedings Vol. 9155:
Translational Biophotonics
Tomasz S. Tkaczyk, Editor(s)

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