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Proceedings Paper

Development and optimization of a line-scanned dual-axis confocal (LS-DAC) microscope for high-speed pathology
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Paper Abstract

We have developed a line-scanned dual-axis confocal (LS-DAC) microscope with subcellular resolution suitable for real time diagnostic imaging at shallow depths. This design serves as a benchtop prototype for a handheld version of the LS-DAC intended for rapid point-of-care pathology. We have assessed the performance trade-offs between the LS-DAC and a point-scanned dual-axis confocal (PS-DAC) microscope via diffraction-theory analysis, Monte-Carlo simulations, and characterization experiments with phantoms and fresh tissues. In addition, we are exploring the use of a sCMOS detector array and rapid 3D deconvolution to improve the sensitivity and resolution of our LS-DAC microscope.

Paper Details

Date Published: 19 May 2014
PDF: 3 pages
Proc. SPIE 9155, Translational Biophotonics, 915515 (19 May 2014); doi: 10.1117/12.2057743
Show Author Affiliations
Danni Wang, Stony Brook Univ. (United States)
Ye Chen, Stony Brook Univ. (United States)
Daphne Meza, Stony Brook Univ. (United States)
Yu Wang, Stony Brook Univ. (United States)
Jonathan T. C. Liu, Stony Brook Univ. (United States)

Published in SPIE Proceedings Vol. 9155:
Translational Biophotonics
Tomasz S. Tkaczyk, Editor(s)

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