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Proceedings Paper

Intradermal administration of fluorescent contrast agents for delivery to axillary lymph nodes
Author(s): John C. Rasmussen; Funda Meric-Berstam; Savitri Krishnamurthy; I-Chih Tan; Banghe Zhu; Jamie L. Wagner; Gildy V. Babiera; Elizabeth A. Mittendorf; Eva M. Sevick-Muraca
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Paper Abstract

In this proof-of-concept study we seek to demonstrate the delivery of fluorescent contrast agent to the tumor-draining lymph node basin following intraparenchymal breast injections and intradermal arm injection of micrograms of indocyanine green in 20 breast cancer patients undergoing complete axillary lymph node dissection. Individual lymph nodes were assessed ex vivo for presence of fluorescent signal. In all, 88% of tumor-negative lymph nodes and 81% of tumor-positive lymph nodes were fluorescent. These results indicate that future studies utilizing targeted fluorescent contrast agents may demonstrate improved surgical and therapeutic intervention.

Paper Details

Date Published: 19 May 2014
PDF: 3 pages
Proc. SPIE 9155, Translational Biophotonics, 91550O (19 May 2014); doi: 10.1117/12.2057640
Show Author Affiliations
John C. Rasmussen, The Univ. of Texas Health Science Ctr. at Houston (United States)
Funda Meric-Berstam, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Savitri Krishnamurthy, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
I-Chih Tan, The Univ. of Texas Health Science Ctr. at Houston (United States)
Banghe Zhu, The Univ. of Texas Health Science Ctr. at Houston (United States)
Jamie L. Wagner, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Gildy V. Babiera, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Elizabeth A. Mittendorf, The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Eva M. Sevick-Muraca, The Univ. of Texas Health Science Ctr. at Houston (United States)


Published in SPIE Proceedings Vol. 9155:
Translational Biophotonics
Tomasz S. Tkaczyk, Editor(s)

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