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Proceedings Paper

Depth sensitive oblique polarized reflectance spectroscopy of oral epithelial tissue
Author(s): Maria K. Jimenez; Sylvia Lam; Catherine Poh; Konstantin Sokolov
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Paper Abstract

Identifying depth-dependent alterations associated with epithelial cancerous lesions can be challenging in the oral cavity where variable epithelial thicknesses and troublesome keratin growths are prominent. Spectroscopic methods with enhanced depth resolution would immensely aid in isolating optical properties associated with malignant transformation. Combining multiple beveled fibers, oblique collection geometry, and polarization gating, oblique polarized reflectance spectroscopy (OPRS) achieves depth sensitive detection. We report promising results from a clinical trial of patients with oral lesions suspected of dysplasia or carcinoma demonstrating the potential of OPRS for the analysis of morphological and architectural changes in the context of multilayer, epithelial oral tissue.

Paper Details

Date Published: 19 May 2014
PDF: 4 pages
Proc. SPIE 9155, Translational Biophotonics, 91550N (19 May 2014); doi: 10.1117/12.2057584
Show Author Affiliations
Maria K. Jimenez, The Univ. of Texas at Austin (United States)
Sylvia Lam, The BC Cancer Agency Research Ctr. (Canada)
Catherine Poh, The BC Cancer Agency Research Ctr. (Canada)
Konstantin Sokolov, The Univ. of Texas at Austin (United States)
The Univ. of Texas M.D. Anderson Cancer Ctr. (United States)

Published in SPIE Proceedings Vol. 9155:
Translational Biophotonics
Tomasz S. Tkaczyk, Editor(s)

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