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Proceedings Paper

ZnSe/ZnS quantum dots - photosensitizer complexes: optical properties and cancer cell photodynamic destruction effect
Author(s): Irina Martynenko; Vera Kuznetsova; Anna Orlova; Pavel Kanaev; Yulia Gromova; Vladimir Maslov; Alex Baranov; Anatoly Fedorov
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Paper Abstract

In present study complexes between non-toxic ZnSe/ZnS quantum dots and chlorin e6 molecules that are widely used as photosensitizers in photodynamic therapy were formed. It was found that in aqueous solution cationic ZnSe/ZnS quantum dots and chlorin e6 formed stable complexes that exhibit efficient photoexcitation energy transfer from quantum dots to molecules. Spectroscopic methods were applied to evaluate the energy transfer efficiency. Stoichiometry of these complexes was studied. Additionally, the photodynamic therapy efficacy of the quantum dotchlorin e6 complexes was in vitro assessed against Ehrlich ascites carcinoma cancer cell line using a trypan blue assay. We found that complex offered an improved cancer cell photodynamic destruction effect as compared to that of free chlorin e6.

Paper Details

Date Published: 2 May 2014
PDF: 8 pages
Proc. SPIE 9126, Nanophotonics V, 91263C (2 May 2014); doi: 10.1117/12.2052528
Show Author Affiliations
Irina Martynenko, National Research Univ. of Information Technologies, Mechanics and Optics (Russian Federation)
Vera Kuznetsova, SAMSON-MED, Pharmaceutical Co., Ltd. (Russian Federation)
Anna Orlova, National Research Univ. of Information Technologies, Mechanics and Optics (Russian Federation)
Pavel Kanaev, SAMSON-MED, Pharmaceutical Co., Ltd. (Russian Federation)
Yulia Gromova, National Research Univ. of Information Technologies, Mechanics and Optics (Russian Federation)
Vladimir Maslov, National Research Univ. of Information Technologies, Mechanics and Optics (Russian Federation)
Alex Baranov, National Research Univ. of Information Technologies, Mechanics and Optics (Russian Federation)
Anatoly Fedorov, National Research Univ. of Information Technologies, Mechanics and Optics (Russian Federation)


Published in SPIE Proceedings Vol. 9126:
Nanophotonics V
David L. Andrews; Jean-Michel Nunzi; Andreas Ostendorf, Editor(s)

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