Share Email Print
cover

Proceedings Paper

In-vitro terahertz spectroscopy of rat skin under the action of dehydrating agents
Author(s): Aleksandr S. Kolesnikov; Ekaterina A. Kolesnikova; Daria K. Tuchina; Artem G. Terentyuk; Maxim Nazarov; Alexander A. Skaptsov; Alexander P. Shkurinov; Valery V. Tuchin
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

In the paper we present the results of study of rat skin and rat subcutaneous tumor under the action of dehydrating agents in terahertz (THz) range (15-30 THz). Frustrated Total Internal Reflection (FTIR) spectra were obtained with infrared Fourier spectrometer Nicolet 6700 and then they were recalculated in the transmittance spectra with Omnic software. Experiments were carried out with healthy and xenografted tumor in skin tissue in vitro. As the dehydrating agents 100% glycerol, 40%-water glucose solution, PEG-600, and propylene glycol were used. To determine the effect of the optical clearing agent (OCA), the alterations of terahertz transmittance for the samples were analyzed. The results have shown that PEG-600 and 40%-glucose water solution are the most effective dehydrating agent. The transmittance of healthy skin after PEG-600 application increased approximately by 6% and the transmittance of tumor tissue after PEG- 600 and 40%-glucose water solution application increased approximately by 8%. Obtained data can be useful for further application of terahertz radiation for tumor diagnostics.

Paper Details

Date Published: 30 January 2014
PDF: 7 pages
Proc. SPIE 9031, Saratov Fall Meeting 2013: Optical Technologies in Biophysics and Medicine XV; and Laser Physics and Photonics XV, 90310D (30 January 2014); doi: 10.1117/12.2052226
Show Author Affiliations
Aleksandr S. Kolesnikov, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
Ekaterina A. Kolesnikova, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
Daria K. Tuchina, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
Artem G. Terentyuk, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
Maxim Nazarov, Institute of Laser and Information Technologies (Russian Federation)
Alexander A. Skaptsov, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
Alexander P. Shkurinov, Lomonosov Moscow State Univ. (Russian Federation)
Valery V. Tuchin, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
Univ. of Oulu (Finland)
Institute of Precise Mechanics and Control (Russian Federation)


Published in SPIE Proceedings Vol. 9031:
Saratov Fall Meeting 2013: Optical Technologies in Biophysics and Medicine XV; and Laser Physics and Photonics XV
Elina A. Genina; Vladimir L. Derbov; Igor Meglinski; Valery V. Tuchin, Editor(s)

© SPIE. Terms of Use
Back to Top