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Proceedings Paper

Pre-processing method to improve optical parameters estimation in Monte Carlo-based inverse problem solving
Author(s): Maria N. Kholodtsova; Victor B. Loschenov; Christian Daul; Walter Blondel
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Paper Abstract

Determining the optical properties of biological tissues in vivo from spectral intensity measurements performed at their surface is still a challenge. Based on spectroscopic data acquired, the aim is to solve an inverse problem, where the optical parameter values of a forward model are to be estimated through optimization procedure of some cost function. In many cases it is an ill-posed problem because of small numbers of measures, errors on experimental data, nature of a forward model output data, which may be affected by statistical noise in the case of Monte Carlo (MC) simulation or approximated values for short inter-fibre distances (for Diffusion Equation Approximation (DEA)). In case of optical biopsy, spatially resolved diffuse reflectance spectroscopy is one simple technique that uses various excitation-toemission fibre distances to probe tissue in depths. The aim of the present contribution is to study the characteristics of some classically used cost function, optimization methods (Levenberg-Marquardt algorithm) and how it is reaching global minimum when using MC and/or DEA approaches. Several methods of smoothing filters and fitting were tested on the reflectance curves, I(r), gathered from MC simulations. It was obtained that smoothing the initial data with local regression weighted second degree polynomial and then fitting the data with double exponential decay function decreases the probability of the inverse algorithm to converge to local minima close to the initial point of first guess.

Paper Details

Date Published: 8 May 2014
PDF: 9 pages
Proc. SPIE 9129, Biophotonics: Photonic Solutions for Better Health Care IV, 91291Q (8 May 2014); doi: 10.1117/12.2051225
Show Author Affiliations
Maria N. Kholodtsova, General Physics Institute (Russian Federation)
Univ. de Lorraine (France)
Ctr. de Recherche en Automatique de Nancy, CNRS (France)
Victor B. Loschenov, General Physics Institute (Russian Federation)
Christian Daul, Univ. de Lorraine (France)
Ctr. de Recherche en Automatique de Nancy, CNRS (France)
Walter Blondel, Univ. de Lorraine (France)
Ctr. de Recherche en Automatique de Nancy, CNRS (France)

Published in SPIE Proceedings Vol. 9129:
Biophotonics: Photonic Solutions for Better Health Care IV
Jürgen Popp; Valery V. Tuchin; Dennis L. Matthews; Francesco Saverio Pavone; Paul Garside, Editor(s)

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