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Zinc oxide nanostructures for electrochemical cortisol biosensingFormat | Member Price | Non-Member Price |
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Paper Abstract
In this paper, we report on fabrication of a label free, highly sensitive and selective electrochemical cortisol
immunosensors using one dimensional (1D) ZnO nanorods (ZnO-NRs) and two dimensional nanoflakes (ZnO-NFs)
as immobilizing matrix. The synthesized ZnO nanostructures (NSs) were characterized using scanning electron
microscopy (SEM), selective area diffraction (SAED) and photoluminescence spectra (PL) which showed that both
ZnO-NRs and ZnO-NFs are single crystalline and oriented in [0001] direction. Anti-cortisol antibody (Anti-Cab) are
used as primary capture antibodies to detect cortisol using electrochemical impedance spectroscopy (EIS). The
charge transfer resistance increases linearly with increase in cortisol concentration and exhibits a sensitivity of 3.078
KΩ. M-1 for ZnO-NRs and 540 Ω. M -1 for ZnO-NFs. The developed ZnO-NSs based immunosensor is capable of
detecting cortisol at 1 pM. The observed sensing parameters are in physiological range. The developed sensors can
be integrated with microfluidic system and miniaturized potentiostat to detect cortisol at point-of-care.
Paper Details
Date Published: 22 May 2014
PDF: 8 pages
Proc. SPIE 9107, Smart Biomedical and Physiological Sensor Technology XI, 91070U (22 May 2014); doi: 10.1117/12.2051156
Published in SPIE Proceedings Vol. 9107:
Smart Biomedical and Physiological Sensor Technology XI
Brian M. Cullum; Eric S. McLamore, Editor(s)
PDF: 8 pages
Proc. SPIE 9107, Smart Biomedical and Physiological Sensor Technology XI, 91070U (22 May 2014); doi: 10.1117/12.2051156
Show Author Affiliations
Phani Kiran Vabbina, Florida International Univ. (United States)
Ajeet Kaushik, Florida International Univ. (United States)
Kathryn Tracy, Florida International Univ. (United States)
Ajeet Kaushik, Florida International Univ. (United States)
Kathryn Tracy, Florida International Univ. (United States)
Shekhar Bhansali, Florida International Univ. (United States)
Nezih Pala, Florida International Univ. (United States)
Nezih Pala, Florida International Univ. (United States)
Published in SPIE Proceedings Vol. 9107:
Smart Biomedical and Physiological Sensor Technology XI
Brian M. Cullum; Eric S. McLamore, Editor(s)
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