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Proceedings Paper

Self-propelled, phage-based magnetoelastic biosentinels for detection of pathogens in liquid
Author(s): Shin Horikawa; Ruiting Zhao; Yating Chai; Howard C. Wikle; Bryan A. Chin
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Paper Abstract

This paper presents the concept of self-propelled magnetoelastic (ME) biosentinels that seek out and capture pathogenic bacteria in stagnant liquids. These biosentinels are composed of a free-standing, asymmetric-shaped ME resonator coated with a filamentous landscape phage that specifically binds with a pathogen of interest. When a time-varying magnetic pulse is applied, the ME biosentinels can be placed into mechanical resonance by magnetostriction. The resultant asymmetric vibration then generates a net force on the surroundings and hence generates autonomous motion in the liquid. As soon as the biosentinels find and bind with the target pathogen through the phage-based biomolecular recognition, a change in the biosentinel’s resonant frequency occurs, and thereby the presence of the target pathogen can be detected. In order to actuate the ME biosentinels into mechanical resonance of a desired mode, modal analysis using the three-dimensional finite element method was performed. In addition, the design of a magnetic chamber that can control the orientation and/or translation of a biosentinel is discussed.

Paper Details

Date Published: 28 May 2014
PDF: 7 pages
Proc. SPIE 9108, Sensing for Agriculture and Food Quality and Safety VI, 910805 (28 May 2014); doi: 10.1117/12.2050533
Show Author Affiliations
Shin Horikawa, Auburn Univ. (United States)
Ruiting Zhao, Auburn Univ. (United States)
Yating Chai, Auburn Univ. (United States)
Howard C. Wikle, Auburn Univ. (United States)
Bryan A. Chin, Auburn Univ. (United States)

Published in SPIE Proceedings Vol. 9108:
Sensing for Agriculture and Food Quality and Safety VI
Moon S. Kim; Kuanglin Chao, Editor(s)

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