Share Email Print
cover

Proceedings Paper

Simple numerical model of OCT signal evolution due to the diffusion of an optical clearing agent
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

A simple numerical model is proposed to describe the process of OCT signal formation in a scattering medium (biological tissue) under the conditions of immersion chemical agent diffusion. Due to optical clearing of the tissue the shape of the OCT A-scan becomes time-dependent, thus providing information about the diffusion rate. The model includes the numerical solution of the diffusion equation, the relation between the concentration of clearing agent and the scattering coefficient, and, finally, the description of the OCT signal formation given the material parameters and with the probe beam geometry taken into account. The test calculations qualitatively reproduce the experimentally observed time behavior of A-scans in samples of human tooth dentine, caused by diffusion of different chemical agents. In particular, it is shown that the non-monotonic A-scans having a maximum can be explained by assuming that the backscattering coefficient giving rise to the OCT signal is, at least partially, subject to optical clearing alongside with the scattering coefficient responsible for the signal attenuation.

Paper Details

Date Published: 30 January 2014
PDF: 9 pages
Proc. SPIE 9031, Saratov Fall Meeting 2013: Optical Technologies in Biophysics and Medicine XV; and Laser Physics and Photonics XV, 90310B (30 January 2014); doi: 10.1117/12.2049685
Show Author Affiliations
Natalia A. Trunina, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
Vladimir L. Derbov, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
Valery V. Tuchin, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)
Institute of Precise Mechanics and Control (Russian Federation)
Univ. of Oulu (Finland)


Published in SPIE Proceedings Vol. 9031:
Saratov Fall Meeting 2013: Optical Technologies in Biophysics and Medicine XV; and Laser Physics and Photonics XV
Elina A. Genina; Vladimir L. Derbov; Igor Meglinski; Valery V. Tuchin, Editor(s)

© SPIE. Terms of Use
Back to Top