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Proceedings Paper

Efficient tissue ablation using a laser tunable in the water absorption band at 3 microns with little collateral damage
Author(s): Alexandra Nierlich; Danail Chuchumishev; Elizabeth Nagel; Kristiana Marinova; Stanislav Philipov; Torsten Fiebig; Ivan Buchvarov; Claus-Peter Richter
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Paper Abstract

Lasers can significantly advance medical diagnostics and treatment. At high power, they are typically used as cutting tools during surgery. For lasers that are used as knifes, radiation wavelengths in the far ultraviolet and in the near infrared spectral regions are favored because tissue has high contents of collagen and water. Collagen has an absorption peak around 190 nm, while water is in the near infrared around 3,000 nm. Changing the wavelength across the absorption peak will result in significant differences in laser tissue interactions. Tunable lasers in the infrared that could optimize the laser tissue interaction for ablation and/or coagulation are not available until now besides the Free Electron Laser (FEL). Here we demonstrate efficient tissue ablation using a table-top mid-IR laser tunable between 3,000 to 3,500 nm. A detailed study of the ablation has been conducted in different tissues. Little collateral thermal damage has been found at a distance above 10-20 microns from the ablated surface. Furthermore, little mechanical damage could be seen in conventional histology and by examination of birefringent activity of the samples using a pair of cross polarizing filters.

Paper Details

Date Published: 4 March 2014
PDF: 6 pages
Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 89262H (4 March 2014); doi: 10.1117/12.2049339
Show Author Affiliations
Alexandra Nierlich, Northwestern Univ. (United States)
Danail Chuchumishev, Northwestern Univ. (Bulgaria)
Sofia Univ. (Bulgaria)
Elizabeth Nagel, Northwestern Univ. (United States)
Kristiana Marinova, Sofia Univ. (Bulgaria)
Stanislav Philipov, Sofia Univ. (Bulgaria)
Torsten Fiebig, Northwestern Univ. (United States)
Ivan Buchvarov, Northwestern Univ. (United States)
Sofia Univ. (Bulgaria)
Claus-Peter Richter, Northwestern Univ. (United States)


Published in SPIE Proceedings Vol. 8926:
Photonic Therapeutics and Diagnostics X
Bernard Choi; Hyun Wook Kang; Brian J. F. Wong M.D.; Guillermo J. Tearney M.D.; Andreas Mandelis; Nikiforos Kollias; Kenton W. Gregory M.D.; Justus F. Ilgner M.D.; Haishan Zeng; Laura Marcu, Editor(s)

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