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Proceedings Paper

Fluorescent nanodiamonds for ultrasensitive detection
Author(s): Joseph Kimball; Dmytro Shumilov; Badri Maliwa; T. W. Zerda; Bibhu Rout; Rafal Fudala; Sangram Raut; Ignacy Gryczynski; Eric Simanek; Julian Borejdo; Ryan Rich; Irina Akopova; Zygmunt Gryczynski
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Paper Abstract

Fluorescent nanodiamonds (NDs) are new and emerging nanomaterials that have potential to be used as fluorescence imaging agents and also as a highly versatile platform for the controlled functionalization and delivery of a wide spectrum of therapeutic agents. We will utilize two experimental methods, TIRF, a relatively simple method based on total internal reflection fluorescence and SPRF, fluorescence enhanced by resonance coupling with surface plasmons. We estimate that the SPRF method will be 100 times sensitive than currently available similar detectors based on detectors. The ultimate goal of this research is to develop microarray platforms that could be used for sensitive, fast and inexpensive gene sequencing and protein detection.

Paper Details

Date Published: 4 March 2014
PDF: 5 pages
Proc. SPIE 8950, Single Molecule Spectroscopy and Superresolution Imaging VII, 89501H (4 March 2014); doi: 10.1117/12.2045376
Show Author Affiliations
Joseph Kimball, Texas Christian Univ. (United States)
Dmytro Shumilov, Texas Christian Univ. (United States)
Badri Maliwa, Univ. of North Texas Health Science Ctr. (United States)
T. W. Zerda, Texas Christian Univ. (United States)
Bibhu Rout, Univ. of North Texas (United States)
Rafal Fudala, Univ. of North Texas Health Science Ctr. (United States)
Sangram Raut, Texas Christian Univ. (United States)
Ignacy Gryczynski, Univ. of North Texas Health Science Ctr. (United States)
Eric Simanek, Texas Christian Univ. (United States)
Julian Borejdo, Univ. of North Texas Health Science Ctr. (United States)
Ryan Rich, Univ. of North Texas Health Science Ctr. (United States)
Irina Akopova, Univ. of North Texas Health Science Ctr. (United States)
Zygmunt Gryczynski, Texas Christian Univ. (United States)
Univ. of North Texas Health Science Ctr. (United States)


Published in SPIE Proceedings Vol. 8950:
Single Molecule Spectroscopy and Superresolution Imaging VII
Jörg Enderlein; Ingo Gregor; Zygmunt Karol Gryczynski; Rainer Erdmann; Felix Koberling, Editor(s)

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