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Proceedings Paper

Methodology for assessment of low level laser therapy (LLLT) irradiation parameters in muscle inflammation treatment
Author(s): M. Mantineo; J. P. Pinheiro; A. M. Morgado
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Paper Abstract

Several studies in human and animals show the clinical effectiveness of low level laser therapy (LLLT) in reducing some types of pain, treating inflammation and wound healing. However, more scientific evidence is required to prove the effectiveness of LLLT since many aspects of the cellular and molecular mechanisms triggered by irradiation of injured tissue with laser remain unknown. Here, we present a methodology that can be used to evaluate the effect of different LLLT irradiation parameters on the treatment of muscle inflammation on animals, through the quantification of four cytokines (TNF-α, IL-1β, IL-2 and IL-6) in systemic blood and histological analysis of muscle tissue. We have used this methodology to assess the effect of LLLT parameters (wavelength, dose, power and type of illumination) in the treatment of inflammation induced in the gastrocnemius muscle of Wistar rats. Results obtained for laser dose evaluation with continuous illumination are presented.

Paper Details

Date Published: 18 November 2013
PDF: 7 pages
Proc. SPIE 9032, Biophotonics—Riga 2013, 90320P (18 November 2013); doi: 10.1117/12.2044689
Show Author Affiliations
M. Mantineo, Univ. de Coimbra (Portugal)
J. P. Pinheiro, Univ. de Coimbra (Portugal)
A. M. Morgado, Univ. de Coimbra (Portugal)

Published in SPIE Proceedings Vol. 9032:
Biophotonics—Riga 2013
Janis Spigulis; Ilona Kuzmina, Editor(s)

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