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Proceedings Paper

Quantitative assessment of biophotonic imaging system performance with phantoms fabricated by rapid prototyping
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Paper Abstract

In biophotonic imaging, turbid phantoms that are low-cost, biologically-relevant, and durable are desired for standardized performance assessment. Such phantoms often contain inclusions of varying depths and sizes in order to quantify key image quality characteristics such as penetration depth, sensitivity and contrast detectability. The emerging technique of rapid prototyping with three-dimensional (3D) printers provides a potentially revolutionary way to fabricate these structures. Towards this goal, we have characterized the optical properties and morphology of phantoms fabricated by two 3D printing approaches: thermosoftening and photopolymerization. Material optical properties were measured by spectrophotometry while the morphology of phantoms incorporating 0.2-1.0 mm diameter channels was studied by μCT, optical coherence tomography (OCT) and optical microscopy. A near-infrared absorbing dye and nanorods at several concentrations were injected into channels to evaluate detectability with a near-infrared hyperspectral reflectance imaging (HRI) system (650-1100 nm). Phantoms exhibited biologically-relevant scattering and low absorption across visible and near-infrared wavelengths. Although limitations in resolution were noted, channels with diameters of 0.4 mm or more could be reliably fabricated. The most significant problem noted was the porosity of phantoms generated with the thermosoftening-based printer. The aforementioned three imaging methods provided a valuable mix of insights into phantom morphology and may also be useful for detailed structural inspection of medical devices fabricated by rapid prototyping, such as customized implants. Overall, our findings indicate that 3D printing has significant potential as a method for fabricating well-characterized, standard phantoms for medical imaging modalities such as HRI.

Paper Details

Date Published: 10 March 2014
PDF: 8 pages
Proc. SPIE 8936, Design and Quality for Biomedical Technologies VII, 89360M (10 March 2014); doi: 10.1117/12.2044089
Show Author Affiliations
Jianting Wang, Univ. of Maryland, College Park (United States)
U.S. Food and Drug Administration (United States)
James Coburn, U.S. Food and Drug Administration (United States)
Nicholas Woolsey, Univ. of Maryland, College Park (United States)
U.S. Food and Drug Administration (United States)
Chia-Pin Liang, Univ. of Maryland, College Park (United States)
Jessica Ramella-Roman, Florida International Univ. (United States)
Yu Chen, Univ. of Maryland, College Park (United States)
U.S. Food and Drug Administration (United States)
Joshua Pfefer, U.S. Food and Drug Administration (United States)


Published in SPIE Proceedings Vol. 8936:
Design and Quality for Biomedical Technologies VII
Ramesh Raghavachari; Rongguang Liang, Editor(s)

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