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Proceedings Paper

Metastatic brain cancer: prediction of response to whole-brain helical tomotherapy with simultaneous intralesional boost for metastatic disease using quantitative MR imaging features
Author(s): Harish Sharma; Glenn Bauman; George Rodrigues; Robert Bartha; Aaron Ward
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Paper Abstract

The sequential application of whole brain radiotherapy (WBRT) and more targeted stereotactic radiosurgery (SRS) is frequently used to treat metastatic brain tumors. However, SRS has side effects related to necrosis and edema, and requires separate and relatively invasive localization procedures. Helical tomotherapy (HT) allows for a SRS-type simultaneous infield boost (SIB) of multiple brain metastases, synchronously with WBRT and without separate stereotactic procedures. However, some patients’ tumors may not respond to HT+SIB, and would be more appropriately treated with radiosurgery or conventional surgery despite the additional risks and side effects. As a first step toward a broader objective of developing a means for response prediction to HT+SIB, the goal of this study was to investigate whether quantitative measurements of tumor size and appearance (including first- and second-order texture features) on a magnetic resonance imaging (MRI) scan acquired prior to treatment could be used to differentiate responder and nonresponder patient groups after HT+SIB treatment of metastatic disease of the brain. Our results demonstrated that smaller lesions may respond better to this form of therapy; measures of appearance provided limited added value over measures of size for response prediction. With further validation on a larger data set, this approach may lead to a means for prediction of individual patient response based on pre-treatment MRI, supporting appropriate therapy selection for patients with metastatic brain cancer.

Paper Details

Date Published: 13 March 2014
PDF: 6 pages
Proc. SPIE 9038, Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging, 90381T (13 March 2014); doi: 10.1117/12.2043758
Show Author Affiliations
Harish Sharma, Robarts Research Institute, The Univ. of Western Ontario (Canada)
Glenn Bauman, Robarts Research Institute, The Univ. of Western Ontario (Canada)
George Rodrigues, Robarts Research Institute, The Univ. of Western Ontario (Canada)
Robert Bartha, Robarts Research Institute, The Univ. of Western Ontario (Canada)
Aaron Ward, Robarts Research Institute, The Univ. of Western Ontario (Canada)


Published in SPIE Proceedings Vol. 9038:
Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging
Robert C. Molthen; John B. Weaver, Editor(s)

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