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Proceedings Paper

A registration-based segmentation method with application to adiposity analysis of mice microCT images
Author(s): Bing Bai; Anand Joshi; Sebastian Brandhorst; Valter D. Longo; Peter S. Conti; Richard M. Leahy
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Paper Abstract

Obesity is a global health problem, particularly in the U.S. where one third of adults are obese. A reliable and accurate method of quantifying obesity is necessary. Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) are two measures of obesity that reflect different associated health risks, but accurate measurements in humans or rodent models are difficult. In this paper we present an automatic, registration-based segmentation method for mouse adiposity studies using microCT images. We co-register the subject CT image and a mouse CT atlas. Our method is based on surface matching of the microCT image and an atlas. Surface-based elastic volume warping is used to match the internal anatomy. We acquired a whole body scan of a C57BL6/J mouse injected with contrast agent using microCT and created a whole body mouse atlas by manually delineate the boundaries of the mouse and major organs. For method verification we scanned a C57BL6/J mouse from the base of the skull to the distal tibia. We registered the obtained mouse CT image to our atlas. Preliminary results show that we can warp the atlas image to match the posture and shape of the subject CT image, which has significant differences from the atlas. We plan to use this software tool in longitudinal obesity studies using mouse models.

Paper Details

Date Published: 9 April 2014
PDF: 6 pages
Proc. SPIE 9038, Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging, 903823 (9 April 2014); doi: 10.1117/12.2043744
Show Author Affiliations
Bing Bai, Univ. of Southern California (United States)
Anand Joshi, Univ. of Southern California (United States)
Sebastian Brandhorst, Univ. of Southern California (United States)
Valter D. Longo, Univ. of Southern California (United States)
Peter S. Conti, Univ. of Southern California (United States)
Richard M. Leahy, Univ. of Southern California (United States)


Published in SPIE Proceedings Vol. 9038:
Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging
Robert C. Molthen; John B. Weaver, Editor(s)

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