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Proceedings Paper

Intraoperative imaging of cortical perfusion by time-resolved thermography using cold bolus approach
Author(s): Julia Hollmach; Christian Schnabel; Nico Hoffmann; Yordan Radev; Stephan Sobottka; Matthias Kirsch; Gabriele Schackert; Edmund Koch; Gerald Steiner
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Paper Abstract

During the past decade, thermographic cameras with high thermal and temporal resolution of up to 30 mK and 50 Hz, respectively, have been developed. These camera systems can be used to reveal thermal variations and heterogeneities of tissue and blood. Thus, they provide a fast, sensitive, noninvasive, and label-free application to investigate blood perfusion and to detect perfusion disorders. Therefore, time-resolved thermography is evaluated and tested for intraoperative imaging of the cerebral cortex during neurosurgeries. The motivation of this study is the intraoperative evaluation of the cortical perfusion by observing the temporal temperature curve of the cortex during and after the intravenous application of a cold bolus. The temperature curve caused by a cold bolus is influenced by thermodilution, depending on the temperature difference to the patient’s circulation, and the pattern of mixing with the patient’s blood. In this initial study, a flow phantom was used in order to determine the temperature variations of cold boli under stable conditions in a vascular system. The typical temperature profile of cold water passing by can be approximated by a bi- Gaussian function involving a set of four parameters. These parameters can be used to assess the cold bolus, since they provide information about its intensity, duration and arrival time. The findings of the flow phantom can be applied to thermographic measurements of the human cortex. The results demonstrate that time-resolved thermographic imaging is a suitable method to detect cold boli not only at a flow phantom but also at the human cortex.

Paper Details

Date Published: 12 March 2014
PDF: 6 pages
Proc. SPIE 9036, Medical Imaging 2014: Image-Guided Procedures, Robotic Interventions, and Modeling, 903627 (12 March 2014); doi: 10.1117/12.2043453
Show Author Affiliations
Julia Hollmach, Technische Univ. Dresden (Germany)
Christian Schnabel, Technische Univ. Dresden (Germany)
Nico Hoffmann, Technische Univ. Dresden (Germany)
Yordan Radev, Klinik und Poliklinik für Neurochirurgie, Technische Univ. Dresden (Germany)
Stephan Sobottka, Klinik und Poliklinik für Neurochirurgie, Technische Univ. Dresden (Germany)
Matthias Kirsch, Klinik und Poliklinik für Neurochirurgie, Technische Univ. Dresden (Germany)
Gabriele Schackert, Klinik und Poliklinik für Neurochirurgie, Technische Univ. Dresden (Germany)
Edmund Koch, Technische Univ. Dresden (Germany)
Gerald Steiner, Technische Univ. Dresden (Germany)


Published in SPIE Proceedings Vol. 9036:
Medical Imaging 2014: Image-Guided Procedures, Robotic Interventions, and Modeling
Ziv R. Yaniv; David R. Holmes, Editor(s)

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