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Proceedings Paper

Alternations of functional connectivity in amblyopia patients: a resting-state fMRI study
Author(s): Jieqiong Wang; Ling Hu; Wenjing Li; Junfang Xian; Likun Ai; Huiguang He
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Paper Abstract

Amblyopia is a common yet hard-to-cure disease in children and results in poor or blurred vision. Some efforts such as voxel-based analysis, cortical thickness analysis have been tried to reveal the pathogenesis of amblyopia. However, few studies focused on alterations of the functional connectivity (FC) in amblyopia. In this study, we analyzed the abnormalities of amblyopia patients by both the seed-based FC with the left/right primary visual cortex and the network constructed throughout the whole brain. Experiments showed the following results: (1)As for the seed-based FC analysis, FC between superior occipital gyrus and the primary visual cortex was found to significantly decrease in both sides. The abnormalities were also found in lingual gyrus. The results may reflect functional deficits both in dorsal stream and ventral stream. (2)Two increased functional connectivities and 64 decreased functional connectivities were found in the whole brain network analysis. The decreased functional connectivities most concentrate in the temporal cortex. The results suggest that amblyopia may be caused by the deficits in the visual information transmission.

Paper Details

Date Published: 13 March 2014
PDF: 8 pages
Proc. SPIE 9038, Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging, 903809 (13 March 2014); doi: 10.1117/12.2043424
Show Author Affiliations
Jieqiong Wang, Institute of Automation (China)
Ling Hu, Beijing Tongren Hospital, Capital Medical Univ. (China)
Wenjing Li, Institute of Automation (China)
Beijing Univ. of Technology (China)
Junfang Xian, Beijing Tongren Hospital, Capital Medical Univ. (China)
Likun Ai, Beijing Tongren Hospital, Capital Medical Univ. (China)
Huiguang He, Institute of Automation (China)


Published in SPIE Proceedings Vol. 9038:
Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging
Robert C. Molthen; John B. Weaver, Editor(s)

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