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Proceedings Paper

Single-shot X-ray measurement of alveolar size distributions
Author(s): Richard P. Carnibella; Marcus J. Kitchen; Andreas Fouras
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Paper Abstract

Regional changes in lung microstructure are an important component of several common lung disorders and even in healthy lungs alveolar mechanics are poorly understood. Existing techniques capable of studying the lung microstructure have various limitations including poor temporal resolution. We present a technique, which can measure the distribution of alveolar diameters from a single, phase contrast chest X-ray. We present the results of analysis of synchrotron images of a rabbit pup’s lungs, which we compare with high-resolution computed tomography images. We demonstrate that measurements can be made with an exposure time of 40 ms, highlighting the unique potential for performing dynamic in vivo measurements. Applications include disease detection, assessment of therapeutics and physiological studies.

Paper Details

Date Published: 13 March 2014
PDF: 7 pages
Proc. SPIE 9038, Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging, 90380V (13 March 2014); doi: 10.1117/12.2043415
Show Author Affiliations
Richard P. Carnibella, Monash Univ. (Australia)
Marcus J. Kitchen, Monash Univ. (Australia)
Andreas Fouras, Monash Univ. (Australia)


Published in SPIE Proceedings Vol. 9038:
Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging
Robert C. Molthen; John B. Weaver, Editor(s)

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