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Proceedings Paper

Multi-atlas segmentation with particle-based group-wise image registration
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Paper Abstract

We propose a novel multi-atlas segmentation method that employs a group-wise image registration method for the brain segmentation on rodent magnetic resonance (MR) images. The core element of the proposed segmentation is the use of a particle-guided image registration method that extends the concept of particle correspondence into the volumetric image domain. The registration method performs a group-wise image registration that simultaneously registers a set of images toward the space defined by the average of particles. The particle-guided image registration method is robust with low signal-to-noise ratio images as well as differing sizes and shapes observed in the developing rodent brain. Also, the use of an implicit common reference frame can prevent potential bias induced by the use of a single template in the segmentation process. We show that the use of a particle guided-image registration method can be naturally extended to a novel multi-atlas segmentation method and improves the registration method to explicitly use the provided template labels as an additional constraint. In the experiment, we show that our segmentation algorithm provides more accuracy with multi-atlas label fusion and stability against pair-wise image registration. The comparison with previous group-wise registration method is provided as well.

Paper Details

Date Published: 21 March 2014
PDF: 8 pages
Proc. SPIE 9034, Medical Imaging 2014: Image Processing, 903447 (21 March 2014); doi: 10.1117/12.2043333
Show Author Affiliations
Joohwi Lee, The Univ. of North Carolina at Chapel Hill (United States)
Ilwoo Lyu, The Univ. of North Carolina at Chapel Hill (United States)
Martin Styner, The Univ. of North Carolina at Chapel Hill (United States)


Published in SPIE Proceedings Vol. 9034:
Medical Imaging 2014: Image Processing
Sebastien Ourselin; Martin A. Styner, Editor(s)

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