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Proceedings Paper

Automated segmentation of corticospinal tract in diffusion tensor images via multi-modality multi-atlas fusion
Author(s): Xiaoying Tang; Susumu Mori; Michael I. Miller
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Paper Abstract

In this paper, we propose a method to automatically segment the corticospinal tract (CST) in diffusion tensor images (DTIs) by incorporating the anatomical features from multi-modality images generated in DTI using multiple DTI atlases. The to-be-segmented test subject, and each atlas, is comprised of images with different modalities – the mean diffusivity, the fractional anisotropy, and the images representing the three elements of the primary eigenvector. Each atlas had a paired image containing the manually delineated segmentations of the three regions of interest - the left and right CST and the background surrounding the CST. We solve the problem via maximum a posteriori estimation using generative models. Each modality image is modeled as a conditional Gaussian mixture random field, conditioned on the atlas-label pair and the local change of coordinates for each label. The expectation-maximization algorithm is used to alternatively estimate the local optimal diffeomorphisms for each label and the maximizing segmentations. The algorithm is evaluated on six subjects with a wide range of pathology. We compare the proposed method with two state-of-the-art multi-atlas based label fusion methods, against which the method displayed a high level of accuracy.

Paper Details

Date Published: 13 March 2014
PDF: 7 pages
Proc. SPIE 9038, Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging, 90381S (13 March 2014); doi: 10.1117/12.2043259
Show Author Affiliations
Xiaoying Tang, Johns Hopkins Univ. (United States)
Susumu Mori, Johns Hopkins Univ. School of Medicine (United States)
Michael I. Miller, Johns Hopkins Univ. (United States)


Published in SPIE Proceedings Vol. 9038:
Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging
Robert C. Molthen; John B. Weaver, Editor(s)

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