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Proceedings Paper

Opto-acoustic breast imaging with co-registered ultrasound
Author(s): Jason Zalev; Bryan Clingman; Don Herzog; Tom Miller; A. Thomas Stavros; Alexander Oraevsky; Kenneth Kist; N. Carol Dornbluth; Pamela Otto
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Paper Abstract

We present results from a recent study involving the ImagioTM breast imaging system, which produces fused real-time two-dimensional color-coded opto-acoustic (OA) images that are co-registered and temporally inter- leaved with real-time gray scale ultrasound using a specialized duplex handheld probe. The use of dual optical wavelengths provides functional blood map images of breast tissue and tumors displayed with high contrast based on total hemoglobin and oxygen saturation of the blood. This provides functional diagnostic information pertaining to tumor metabolism. OA also shows morphologic information about tumor neo-vascularity that is complementary to the morphological information obtained with conventional gray scale ultrasound. This fusion technology conveniently enables real-time analysis of the functional opto-acoustic features of lesions detected by readers familiar with anatomical gray scale ultrasound. We demonstrate co-registered opto-acoustic and ultrasonic images of malignant and benign tumors from a recent clinical study that provide new insight into the function of tumors in-vivo. Results from the Feasibility Study show preliminary evidence that the technology may have the capability to improve characterization of benign and malignant breast masses over conventional diagnostic breast ultrasound alone and to improve overall accuracy of breast mass diagnosis. In particular, OA improved speci city over that of conventional diagnostic ultrasound, which could potentially reduce the number of negative biopsies performed without missing cancers.

Paper Details

Date Published: 13 March 2014
PDF: 7 pages
Proc. SPIE 9038, Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging, 90381J (13 March 2014); doi: 10.1117/12.2043050
Show Author Affiliations
Jason Zalev, Seno Medical Instruments, Inc. (United States)
Bryan Clingman, Seno Medical Instruments, Inc. (United States)
Don Herzog, Seno Medical Instruments, Inc. (United States)
Tom Miller, Seno Medical Instruments, Inc. (United States)
A. Thomas Stavros, Seno Medical Instruments, Inc. (United States)
Alexander Oraevsky, TomoWave Labs., Inc. (United States)
Kenneth Kist, The Univ. of Texas Health Science Ctr. at San Antonio (United States)
N. Carol Dornbluth, The Univ. of Texas Health Science Ctr. at San Antonio (United States)
Pamela Otto, The Univ. of Texas Health Science Ctr. at San Antonio (United States)


Published in SPIE Proceedings Vol. 9038:
Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging
Robert C. Molthen; John B. Weaver, Editor(s)

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