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Proceedings Paper

Low-power laser irradiation (LPLI) attenuates microglial cytotoxicity through the activation of Src pathway
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Paper Abstract

It has been known for a long time that microglial activation plays an important role in the pathology of neurodegenerative diseases. Once activated, they have macrophage-like capabilities, which can be detrimental by producing proinflammatory and neurotoxic factors including cytokines, reactive oxygen species (ROS) and nitric oxide that directly or indirectly cause neurodegeneration. Therefore, the regulation of microglial-induced neuroinflammation is considered a useful strategy in searching for neuroprotective treatments. In this study, our results showed that low power laser irradiation (LPLI) (20 J/cm2) could suppress microglial-induced neuroinflammation in LPS-activated microglia. We found that LPLI-mediated neuroprotection was achieved by activating tyrosine kinases Src, which led to MyD88 tyrosine phosphorylation, thus impairing MyD88-dependent proinflammatory signaling cascade. Our research may provide a feasible therapeutic approach to control the progression of neurodegenerative diseases.

Paper Details

Date Published: 27 February 2014
PDF: 13 pages
Proc. SPIE 8944, Biophotonics and Immune Responses IX, 89440Y (27 February 2014); doi: 10.1117/12.2042415
Show Author Affiliations
Sheng Song, South China Normal Univ. (China)
Feifan Zhou, South China Normal Univ. (China)
Wei R. Chen, South China Normal Univ. (China)
Univ. of Central Oklahoma (United States)

Published in SPIE Proceedings Vol. 8944:
Biophotonics and Immune Responses IX
Wei R. Chen, Editor(s)

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