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Proceedings Paper

A newly designed optical biochip for a TDM-POCT device
Author(s): C. Berrettoni; C. Trono; S. Berneschi; A. Giannetti; S. Tombelli; R. Bernini; A. Grimaldi; G. Persichetti; G. Testa; L. Bolzoni; G. Porro; H. Becker; C. Gärtner; F. Baldini
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Paper Abstract

The design of a novel therapeutic drug monitoring (TDM) point-of-care-testing (POCT) biochip for immunosuppressants detection in transplanted patients is described. The chip consists of two polymeric parts, a top PMMA slide and a bottom ZEONOR® thin foil, bonded together by means of a pressure sensitive adhesive tape. The tape, with lower refractive index, is shaped in order to obtain a microfluidic multi-channel array. The optical signal, coming from an external light source and travelling along the ZEONOR® thin foil, excites the fluorescent sensing layer immobilized onto the fluidic channels. Preliminary tests with the bioassay implementation for tacrolimus detection are reported.

Paper Details

Date Published: 6 March 2014
PDF: 6 pages
Proc. SPIE 8976, Microfluidics, BioMEMS, and Medical Microsystems XII, 89760P (6 March 2014); doi: 10.1117/12.2042389
Show Author Affiliations
C. Berrettoni, Univ. degli Studi di Siena (Italy)
IFAC-CNR (Italy)
C. Trono, IFAC-CNR (Italy)
S. Berneschi, IFAC-CNR (Italy)
A. Giannetti, IFAC-CNR (Italy)
S. Tombelli, IFAC-CNR (Italy)
R. Bernini, IREA-CNR (Italy)
A. Grimaldi, IREA-CNR (Italy)
G. Persichetti, IREA-CNR (Italy)
G. Testa, IREA-CNR (Italy)
L. Bolzoni, Datamed S.r.L. (Italy)
G. Porro, Datamed S.r.L. (Italy)
H. Becker, microfluidic ChipShop GmbH (Germany)
C. Gärtner, microfluidic ChipShop GmbH (Germany)
F. Baldini, IFAC-CNR (Italy)

Published in SPIE Proceedings Vol. 8976:
Microfluidics, BioMEMS, and Medical Microsystems XII
Bonnie L. Gray; Holger Becker, Editor(s)

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