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Proceedings Paper

Dual plasmonic gold nanoparticles for multispectral photoacoustic imaging application
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Paper Abstract

Nanoparticle contrast agents for molecular targeted imaging have widespread interest in diagnostic applications with cellular resolution, specificity and selectivity for visualization and assessment of various disease processes. Of particular interest is gold nanoparticle owing to its tunability of the surface plasmon resonance (SPR) and its relative inertness. Here we present the synthesis of anisotropic multi-branched star shaped gold nanoparticles exhibiting dual-band plasmon absorption peaks and its application as a contrast agent for multispectral photoacoustic imaging. The transverse plasmon absorption peak of the synthesised dual plasmonic gold nanostar (DPGNS) was around 700 nm and that of longitudinal plasmon absorption in the longer wavelength region around 1050-1150 nm. Unlike most reported PA contrast agent with surface plasmon absorption in the range of 700 to 800 nm showing moderate tissue penetration, 1050-1200 nm range lies in the farther region of the optical window of biological tissue where scattering and the intrinsic optical extinction of endogenous chromophores is at its minimum. We also present a proof of principle demonstration of DPGNS as contrast agent for multispectral photoacoustic animal imaging. Our results show that DPGNS are promising for PA imaging with extended-depth imaging applications.

Paper Details

Date Published: 3 March 2014
PDF: 13 pages
Proc. SPIE 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 89434J (3 March 2014); doi: 10.1117/12.2042079
Show Author Affiliations
Vijay Raghavan, National Univ. of Ireland, Galway (Ireland)
Hrebesh Subhash, National Univ. of Ireland, Galway (Ireland)
Aedán Breathnach, National Univ. of Ireland, Galway (Ireland)
Martin Leahy, National Univ. of Ireland, Galway (Ireland)
Royal College of Surgeons (Ireland)
Peter Dockery, National Univ. of Ireland, Galway (Ireland)
Malini Olivo, National Univ. of Ireland, Galway (Ireland)
Royal College of Surgeons (Ireland)
Singapore Bioimaging Consortium (Singapore)


Published in SPIE Proceedings Vol. 8943:
Photons Plus Ultrasound: Imaging and Sensing 2014
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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