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Proceedings Paper

Temporal correlation of optical coherence tomography in-vivo images of rabbit airway for the diagnosis of edema
Author(s): DongYel Kang; Alex Wang; Tjoson Tjoa; Veronika Volgger; Ashley Hamamoto; Erica Su; Joseph Jing; Zhongping Chen; Brian J. F. Wong
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Paper Abstract

Recently, full-range optical coherence tomography (OCT) systems have been developed to image the human airway. These novel systems utilize a fiber-based OCT probe which acquires three-dimensional (3-D) images with micrometer resolution. Following an airway injury, mucosal edema is the first step in the body’s inflammatory response, which occasionally leads to airway stenosis, a life-threatening condition for critically ill newborns. Therefore, early detection of edema is vital for airway management and prevention of stenosis. In order to examine the potential of the full-range OCT to diagnose edema, we investigated temporal correlation of OCT images obtained from the subglottic airway of live rabbits. Temporally correlated OCT images were acquired at fixed locations in the rabbit subglottis of either artificially induced edema or normal tissues. Edematous tissue was experimentally modeled by injecting saline beneath the epithelial layer of the subglottic mucosa. The calculated cross temporal correlations between OCT images of normal airway regions show periodicity that correlates with the respiratory motion of the airway. However, the temporal correlation functions calculated from OCT images of the edematous regions show randomness without the periodic characteristic. These in-vivo experimental results of temporal correlations between OCT images show the potential of a computer-based or -aided diagnosis of edema in the human respiratory mucosa with a full-range OCT system.

Paper Details

Date Published: 4 March 2014
PDF: 4 pages
Proc. SPIE 8934, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII, 89342R (4 March 2014); doi: 10.1117/12.2042025
Show Author Affiliations
DongYel Kang, Beckman Laser Institute and Medical Clinic (United States)
HanBat National Univ. (Korea, Republic of)
Alex Wang, Beckman Laser Institute and Medical Clinic (United States)
Tjoson Tjoa, Beckman Laser Institute and Medical Clinic (United States)
Veronika Volgger, Beckman Laser Institute and Medical Clinic (United States)
Klinikum der Univ. München (Germany)
Ashley Hamamoto, Beckman Laser Institute and Medical Clinic (United States)
Erica Su, Beckman Laser Institute and Medical Clinic (United States)
Joseph Jing, Beckman Laser Institute and Medical Clinic (United States)
Zhongping Chen, Beckman Laser Institute and Medical Clinic (United States)
Brian J. F. Wong, Beckman Laser Institute and Medical Clinic (United States)


Published in SPIE Proceedings Vol. 8934:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII
Joseph A. Izatt; James G. Fujimoto; Valery V. Tuchin, Editor(s)

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