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Proceedings Paper

Towards an atrio-ventricular delay optimization assessed by a computer model for cardiac resynchronization therapy
Author(s): David Ojeda; Virginie Le Rolle; Kevin Tse Ve Koon; Christophe Thebault; Erwan Donal; Alfredo I. Hernández
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Paper Abstract

In this paper, lumped-parameter models of the cardiovascular system, the cardiac electrical conduction system and a pacemaker are coupled to generate mitral ow pro les for di erent atrio-ventricular delay (AVD) con gurations, in the context of cardiac resynchronization therapy (CRT). First, we perform a local sensitivity analysis of left ventricular and left atrial parameters on mitral ow characteristics, namely E and A wave amplitude, mitral ow duration, and mitral ow time integral. Additionally, a global sensitivity analysis over all model parameters is presented to screen for the most relevant parameters that a ect the same mitral ow characteristics. Results provide insight on the in uence of left ventricle and atrium in uence on mitral ow pro les. This information will be useful for future parameter estimation of the model that could reproduce the mitral ow pro les and cardiovascular hemodynamics of patients undergoing AVD optimization during CRT.

Paper Details

Date Published: 19 November 2013
PDF: 10 pages
Proc. SPIE 8922, IX International Seminar on Medical Information Processing and Analysis, 892207 (19 November 2013); doi: 10.1117/12.2041977
Show Author Affiliations
David Ojeda, INSERM (France)
LTSI, CNRS, Univ. de Rennes 1 (France)
Virginie Le Rolle, INSERM (France)
LTSI, CNRS, Univ. de Rennes 1 (France)
Kevin Tse Ve Koon, INSERM (France)
LTSI, CNRS, Univ. de Rennes 1 (France)
Christophe Thebault, INSERM (France)
LTSI, CNRS, Univ. de Rennes 1 (France)
CHU Rennes, Service de Chirurgie Thoracique et de Chirurgie Vasculaire. Rennes (France)
Erwan Donal, INSERM (France)
LTSI, CNRS, Univ. de Rennes 1 (France)
CHU Rennes, Service de Chirurgie Thoracique et de Chirurgie Vasculaire, Rennes (France)
Alfredo I. Hernández, INSERM (France)
LTSI, CNRS, Univ. de Rennes 1 (France)


Published in SPIE Proceedings Vol. 8922:
IX International Seminar on Medical Information Processing and Analysis
Jorge Brieva; Boris Escalante-Ramírez, Editor(s)

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