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Proceedings Paper

Microvascular anastomosis in rodent model evaluated by Fourier domain Doppler optical coherence tomography
Author(s): Yong Huang; Dedi Tong; Shan Zhu; Lehao Wu; Zuhaib Ibrahim; WP Andrew Lee; Gerald Brandacher; Jin U. Kang
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Paper Abstract

Vascular and microvascular anastomosis are critical components of reconstructive microsurgery, vascular surgery and transplant surgery. Imaging modality that provides immediate, real-time in-depth view and 3D structure and flow information of the surgical site can be a great valuable tool for the surgeon to evaluate surgical outcome following both conventional and innovative anastomosis techniques, thus potentially increase the surgical success rate. Microvascular anastomosis for vessels with outer diameter smaller than 1.0 mm is extremely challenging and effective evaluation of the outcome is very difficult if not impossible using computed tomography (CT) angiograms, magnetic resonance (MR) angiograms and ultrasound Doppler. Optical coherence tomography (OCT) is a non-invasive high-resolution (micron level), high-speed, 3D imaging modality that has been adopted widely in biomedical and clinical applications. Phaseresolved Doppler OCT that explores the phase information of OCT signals has been shown to be capable of characterizing dynamic blood flow clinically. In this work, we explore the capability of Fourier domain Doppler OCT as an evaluation tool to detect commonly encountered post-operative complications that will cause surgical failure and to confirm positive result with surgeon’s observation. Both suture and cuff based techniques were evaluated on the femoral artery and vein in the rodent model.

Paper Details

Date Published: 4 March 2014
PDF: 8 pages
Proc. SPIE 8934, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII, 893425 (4 March 2014); doi: 10.1117/12.2041975
Show Author Affiliations
Yong Huang, Johns Hopkins Univ. (United States)
Dedi Tong, Johns Hopkins Univ. School of Medicine (United States)
Beijing Jishuitan Hospital (China)
Shan Zhu, Johns Hopkins Univ. School of Medicine (United States)
Peking Union Medical College, Chinese Academy of Medical Science (China)
Lehao Wu, Johns Hopkins Univ. School of Medicine (United States)
Zuhaib Ibrahim, Johns Hopkins Univ. School of Medicine (United States)
WP Andrew Lee, Johns Hopkins Univ. School of Medicine (United States)
Gerald Brandacher, Johns Hopkins Univ. School of Medicine (United States)
Jin U. Kang, Johns Hopkins Univ. (United States)


Published in SPIE Proceedings Vol. 8934:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVIII
Joseph A. Izatt; James G. Fujimoto; Valery V. Tuchin, Editor(s)

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