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Proceedings Paper

Multi-parametric imaging of cerebral hemodynamic and metabolic response followed by ischemic injury
Author(s): Jia Qin; Lei Shi; Suzan Dziennis; Ruikang K. Wang
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Paper Abstract

We use rodent parietal cortex as a model system and utilize a synchronized dual wavelength laser speckle imaging (SDW-LSCI) technique to explore the hemodynamic response of infarct and penumbra to a brain injury (middle cerebral artery occlusion (MCAO) model). The SDW-LSCI system is able to take snapshots rapidly (maximum 500 Hz) over the entire brain surface, providing key information about the hemodynamic response, in terms of which it may be used to elucidate evolution of penumbra region from onsite to 90 min of MCAO. Changes in flow are quantified as to the flow experiencing physical occlusions of the MCA normalized to that of baseline. Furthermore, the system is capable of providing information as to the changes of the concentration of oxygenated, (HbO) deoxygenated (Hb), and total hemoglobin (HbT) in the cortex based on the spectral characteristics of HbO and Hb. We observe that the oxygenation variations in the four regions are detectable and distinct. Combining the useful information, four regions of interest (ROI), infarct, penumbra, reduced flow and contralateral portions in the brain upon ischemic injury may be differentiated. Implications of our results are discussed with respect to current understanding of the mechanisms underlying MCAO. We anticipate that SDW-LSCI holds promise for rapid and large field of view localization of ischemic injury.

Paper Details

Date Published: 26 February 2014
PDF: 6 pages
Proc. SPIE 8942, Dynamics and Fluctuations in Biomedical Photonics XI, 89420U (26 February 2014); doi: 10.1117/12.2041699
Show Author Affiliations
Jia Qin, Northeastern Univ. at Qinhuangdao (China)
Univ. of Washington (United States)
Lei Shi, Northeastern Univ. at Qinhuangdao (China)
Univ. of Washington (United States)
Suzan Dziennis, Northeastern Univ. at Qinhuangdao (China)
Univ. of Washington (United States)
Ruikang K. Wang, Northeastern Univ. at Qinhuangdao (China)
Univ. of Washington (United States)


Published in SPIE Proceedings Vol. 8942:
Dynamics and Fluctuations in Biomedical Photonics XI
Valery V. Tuchin; Donald D. Duncan; Kirill V. Larin; Martin J. Leahy; Ruikang K. Wang, Editor(s)

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